Symptoms causes and possible solutions of Dementia

Symptoms causes and possible solutions of Dementia Introduction (source, NHS) Dementia is a syndrome (a group of related symptoms) that is associated with an ongoing decline  of the brain and its  abilities. These include: thinking, language, memory,  Ã‚   understanding, and judgement. People with dementia may also have problems controlling their emotions or  behaving appropriately in social situations. Aspects of their personality may change. Most cases of dementia are caused by damage to the structure of the brain. How common is dementia? Dementia is a common condition. In  England alone, there are currently 570,000 people living with dementia. That number is expected to double over the next 30 years. Usually dementia occurs in people who are 65  or over. The older you get, the more likely you are to develop it. It is estimated that dementia occurs in: 1.4% of men and 1.5% of women aged between 65 and 69, 3.1% of men and 2.2% of women aged between 70 and 74, 5.6% of men and 7.1% of women aged between 75 and 79, 10.2 % of men and 14.1% of women aged between 80 and 84, and 19.6% of men and 27.5% of women aged 85 or over. Types of dementia Listed below are the different types of dementia. Alzheimers disease, where small clumps of protein, known as plaques, begin to develop around brain cells. This disrupts the normal workings of the brain. Vascular dementia, where problems with blood circulation result in parts of the brain not receiving enough blood and oxygen. Dementia with Lewy bodies, where abnormal structures, known as Lewy bodies, develop inside the brain. Frontotemporal dementia, where the frontal and temporal lobes (two parts of the brain) begin to shrink. Unlike other types of dementia, frontotemporal dementia usually develops in people who are under 65. It is much rarer than other types of dementia. This  section focuses on vascular dementia, dementia with Lewy bodies and frontotemporal dementia. See Useful links for more information about Alzheimers disease. Outlook In clinical terms, the outlook for dementia is not good. In most cases, there is no cure  and symptoms will get worse over time. However, even if a persons dementia cannot be cured, there are a number of effective treatments that can help them to cope better with their symptoms and improve their quality of life. Symtoms Vascular dementia The symptoms of vascular dementia can develop suddenly and quickly  worsen.  Or they can develop gradually over  many months. Symptoms  include: increasing difficulties with tasks and activities that require concentration and planning, memory loss, depression, changes in personality and mood, periods of mental confusion, low attention span, urinary incontinence, stroke-like symptoms, such as muscle weakness or paralysis on one side of the body, wandering during the night, and slow and unsteady gait (the way that you walk). Symptoms of dementia with Lewy bodies The symptoms of dementia with Lewy bodies usually develop gradually  but get  more severe over the course of many years. The symptoms of dementia with Lewy bodies include: memory loss, low attention span, periods of mental confusion, delusions (believing in things that are not true), difficulty planning ahead, muscle stiffness, slower movement, shaking and trembling of arms and legs, shuffling while walking, problems sleeping,   loss of facial expression, and visual hallucinations (seeing things that are not  there). Usually people will see other people or animals that are not real. Symptoms of frontotemporal dementia Frontotemporal dementia is caused by damage to the parts of the brain that help control emotional responses and behaviour. Therefore, many of the initial symptoms of frontotemporal dementia involve changes in emotion, personality and behaviour. Someone with frontotemporal dementia may  become less sensitive to other peoples emotions. This can make them  seem cold and unfeeling. They may also lose some of their inhibitions. This could lead to strange behaviour, such as  making sexually suggestive gestures in a public place, being rude to others or making tactless comments. Other symptoms of frontotemporal dementia include: aggression, compulsive behaviour, being easily distracted, an increasing lack of interest in washing themselves, and personality changes. A  person who was previously withdrawn may become very outgoing, or vice versa. Some people with frontotemporal dementia also  have problems with language. Symptoms affecting language include: speaking far less than usual, or not speaking at all, having problems finding the right words to express themselves, and using many words to describe something simple. For example, saying a metal and wooden tool used for digging instead of a spade Causes of dementia   Vascular dementia Vascular dementia is caused when there is an interruption to the blood supply to the brain. Like all organs, in order to  work properly the brain needs a constant supply of oxygen and nutrients that is provided by the blood. If the supply of blood is restricted or stopped, brain cells begin to die, resulting in brain damage. The blood supply to the brain can become blocked during a stroke where either: a blood clot blocks the supply of blood to the brain, known as an ischaemic stroke, or a blood vessel becomes weakened and then splits. This is known as a haemorrhagic stroke. Sometimes, less severe blockages to the brain do not result in a stroke, but they can damage the brain to a lesser extent. This is known as a silent brain infarction. Not everyone who has had a stroke or a silent brain infarction will go on to  get vascular dementia. But  it always remains a possibility, particularly in people who have multiple strokes or silent brain infarctions. Vascular dementia can also develop if the vessels inside the brain narrow and harden. Narrowing and hardening of the blood vessels is known as arteriosclerosis. Know risk factors for arteriosclerosis include: diabetes, obesity, smoking, drinking  too much  alcohol, lack of exercise, and eating a high-fat diet Dementia with Lewy bodies Lewy bodies are small, circular  lumps of protein that develop inside the brain. It is not known what causes  them. It is also unclear how  they damage the brain and cause dementia. One theory is that they block the effects of two neurotransmitters called dopamine and acetylcholine. Neurotransmitters are messenger chemicals that send information from one brain cell to another. Both dopamine and acetylcholine are thought to play an important role in helping to regulate many important mental functions, such as memory, learning, mood and attention. Therefore, by blocking their effects, Lewy bodies may trigger dementia. Frontotemporal dementia Frontotemporal dementia is caused by two parts of the brain (the temporal lobe and the frontal lobe) becoming increasingly damaged and then shrinking. In an estimated 40 to 50% of cases, people who develop frontotemporal dementia have inherited a genetic mutation (an altered gene) from their parents. These genetic mutations are thought to  have a negative effect on a protein known as the tau protein. All brain cells contain tau proteins. They help to keep the brain cells stable. However, if tau proteins stop working properly, they can damage brain cells. If  no genetic mutation  is found, the causes of frontotemporal dementia  remain unknown. Less common causes of dementia Dementia or dementia-like symptoms can have a number of less common causes, some of which are treatable. These include: repeated  injury to the head, infections of the brain, such as meningitis or encephalitis, Huntingtons disease, a rare genetic condition that causes progressive brain damage, Creutzfeldt-Jakob disease (CJD), a rare and fatal condition that causes damage to the brain and nervous system, an overactive or underactive thyroid gland, dehydration, lack of  vitamin B in the diet, poisoning,  for example from lead or pesticides,   having a brain tumour, and certain lung and heart conditions that interrupt the supply of blood and oxygen to the brain. Diagnosing dementia   Confirming a diagnosis of dementia can be difficult, particularly when the condition is in its early stages. This is because many of the symptoms of dementia can be caused by other  conditions. In order  for dementia to be  diagnosed correctly, you should  have a number of different tests and assessments including: A  review of your medical history. A  full assessment of your mental abilities.   A range of  tests,  including blood tests to rule out other possible causes of your symptoms, such as a vitamin B deficiency. Imaging scans, such as a magnetic resonance imaging (MRI) scan, which can provide information about the physical state and structure of your brain. A  review of any medication you may be taking, in case these are contributing to your symptoms. Some of these tests can be carried out by your GP. Others will be carried out by other specialists, such as a neurologist (an expert in treating conditions that affect the brain and nervous system) or a psychiatrist with experience in treating dementia. Assessing your mental abilities There are some questionnaires that can be used to help  test your mental abilities and how severe your symptoms are. One widely used questionnaire is the  Mini Mental State Examination (MMSE). The MMSE can be used to assess a number of different mental abilities including: short- and long-term memory, attention span, concentration, language and communication skills, ability to plan, and ability to understand instructions. The MMSE is a series of questions, each carrying a score that can give a maximum result of 30 points. Example questions include: memorising a short list of objects and then repeat the list back, writing a short sentence that is grammatically correct, such as the dog sat on the floor, and correctly indentifying the current day of the week, followed by the date, the month, the season and the year. While the MMSE cannot diagnosis dementia by itself, it is  useful for assessing the level of mental impairment that a person with dementia may have. A  score of 25 or above is considered normal. A  score of 18 to 24 indicates mild to moderate impairment. A  score of 17 or below indicates serious impairment. Ruling out other conditions There are  further tests that can be used to rule out other conditions that may be responsible for the patients symptoms. These tests are outlined below. A full blood count A full blood count can be used to assess your general health and check for a range of disorders, including anaemia and infection. A blood sample will usually be taken from a vein in your arm using a needle and syringe. The test will also check for other illnesses. Blood glucose test A blood glucose test can be used to determine whether your blood glucose level is normal, and can also determine whether you have diabetes. A blood sample is taken to rule out whether your symptoms might be caused by undiagnosed diabetes. Urine analysis Urine analysis is used to diagnose diabetes or problems with your kidneys. During the test, you will be asked to pass a small sample of urine into a sterile container. Measurement of thyroid hormones A measurement of your thyroid hormones may be taken in order to screen for thyroid disorders, including hypothyroidism (an underactive thyroid) and hyperthyroidism (an overactive thyroid).   Measurement of vitamin B12 levels You may also have a test to check  whether your symptoms are caused by a lack of vitamin B12. However, if  you do  have a B12 deficiency, it is still possible that you may also have dementia. Imaging scans Imaging scans can check if there are any underlying problems with your brain, such as a brain tumour, that could  help explain  your symptoms. Imaging scans can also identify changes in the appearance of the brain that may indicate dementia. Several types of imaging scans can be used in the diagnosis of dementia. These are described below. Magnetic resonance imaging A magnetic resonance imaging (MRI) scan is the best way to rule out other brain problems, and to help diagnose the type of dementia. MRI scans help doctors determine whether: there is any shrinkage to the outer layer of the brain, there is any evidence of changes to the blood vessels, or there are any blood clots that might have resulted in vascular dementia. The test will also show whether other conditions, such as a brain tumour, are causing your symptoms. Computerised topography A computerised topography (CT) scan can be used as an alternative to a MRI scan. A CT scan takes a series of X-ray images of your brain. The images are fed into a computer to build up a detailed  3D image of the inside of your brain. Single photon-emission computed tomography A single photon-emission computed tomography (SPECT) scan may be recommended if doctors are unsure whether you have Alzheimers disease, frontotemporal dementia or vascular dementia. A SPECT scan is similar to a CT scan, but the scanner used for a SPECT scan is able to take moving pictures of the blood flow in your brain. The results show if the blood flow in your brain is abnormal, which can often be used to help diagnose the type of dementia. Treating dementia   Your care plan If you are diagnosed with dementia, your future health and social care needs will be assessed and a care plan will be drawn up. A care plan is a way of ensuring that you receive the right treatment for your needs. Examples of questions that could  come up  while drawing up your care plan are listed below. Do  you have a family member or friend willing to act as a carer? What support do you or your carer need for you  to remain as independent as possible? Are there  any changes that need to be made to your  home to make it easier to live in? Would you benefit from physical and occupational therapy? Do  you need additional treatment and advice to help you cope with symptoms of incontinence? Might you require residential care at some point in the future? It is important to remember that this is your care plan. You should ask as many questions as you want and make sure that your wishes are known. Patient consent and advanced directive Patient consent means that you have to give express permission before any medical treatment can be carried out on you. Consent is needed for all  treatments, whether its a simple blood test or an organ donation. The only  time when treatment can go ahead without your  permission is if you  are unable to  make a decision on your own, and the  doctors responsible for your care believe that treatment is in your best interests. There may be a time in the future when your symptoms mean that you  are no longer able  to give consent. Therefore, you may wish to draw up an advanced directive after first receiving a diagnosis of dementia.   An advanced directive  makes your treatment preferences known now, in case you are not able to do this later. Subjects  covered by  an advanced directive can include: what treatment you would consider having and in what circumstances, what types of treatment you would never wish to have, no matter what the circumstances, what type of end-of-life care you would wish to have, for example, whether you would want to be resuscitated by artificial means, such as having a breathing tube inserted into your neck if you  have lung failure, and whether you would be willing to donate organs after your death. You cannot request anything illegal in your advanced directive, such as assisted suicide. Your care team will be able to provide you with more information and advice about advanced directives. You may wish to appoint a friend or family member to take care of your financial and legal affairs. This is known as granting power of attorney. See  Useful links  for information and advice about granting power of attorney. Psychological treatments There are a number of different psychological treatments that can be used to help you cope  with the symptoms of dementia and slow down the  symptoms. These  are described  below. Cognitive stimulation Cognitive stimulation involves taking part in activities and exercises that are designed to improve your memory, problem-solving skills and language ability. It  is provided by a trained carer, and usually consists of two 45-minute sessions a week. During these, you will be involved in discussions about a variety of topics, as well as taking part in word and memory games, and other activities, such as trying to identify pictures of famous people. Behavioural therapy Behavioural therapy is used to help treat many of the behavioural problems that are associated with dementia, such as depression, aggression and delusional thinking. Behavioural therapy is usually provided by a carer, who can be a trained friend, relative or an employed carer. It is  supervised by  a health professional. Behavioural therapy uses a problem-solving approach where possible motivations and reasons for troublesome behaviour are identified. Different strategies are adopted to try to change that behaviour. For example, a person with dementia may have a history of wandering out of their home or care centre because they feel restless. Therefore, a strategy that involves encouraging them to take part in regular physical exercise may  lessen their restlessness.   Reality orientation therapy Reality orientation therapy is a type of therapy  that reduces  feelings of mental disorientation, memory loss and confusion, while improving feelings of self-esteem. Reality orientation therapy may involve group work in a classroom, in which a board prominently displays information such as: the current day and date, the location of the classroom, and the names of the people in the group. The group members repeat  a series of tasks that are designed to  give mental stimulation. These tasks also  reinforce information regarding the time, the place  and the people involved in the group. Multisensory stimulation Multisensory stimulation is a way of stimulating the brain  using different elements. These include  lighting, relaxing music and sounds, massage cushions, aromatherapy (scents) and different touch sensations. By stimulating different areas of the brain, multisensory stimulation aims to lessen feelings of confusion and restlessness, and  improve mood and language skills. However,  this treatment is not suitable  for everyone with dementia, as some people find the effects of stimulation upsetting and unpleasant. Exercise therapy Exercise therapy consists of either general fitness training or a structured fitness programme. It is designed to improve a persons physical mobility, as well as benefiting mental function and mood. Medicines Acetylcholinesterase inhibitors Acetylcholinesterase inhibitors (AIs) are widely used to treat Alzheimers disease. They are not usually recommended for other forms of dementia because the evidence for their effectiveness is limited and, in some cases, may make symptoms worse. One exception is for people living with dementia with Lewy bodies that have behavioural problems, such as delusions or hallucinations,  which are causing them significant distress or leading to challenging behaviour. AIs  work by preventing the breakdown of the neurotransmitter acetylcholine, as low levels of acetylcholine have been linked to behavioural problems. Side effects include: nausea, vomiting, diarrhoea, muscle cramps, fatigue, loss of appetite, agitation, aggressive behaviour, dizziness and fainting, insomnia, and urinary incontinence. Antipsychotics Antipsychotics are medicines that can be used to treat challenging and disruptive behaviour, such as aggression or agitation. However, antipsychotics are not usually recommended for the treatment of dementia because: they can increase the risk of a person experiencing cardiovascular diseases, such as strokes, and they can make the symptoms of dementia worse. Also, in people who have dementia with Lewy bodies there is evidence that antipsychotics can cause a range of serious side effects, such as: rigidity, immobility, being unable  to perform tasks, being unable  to communicate and,  possibly, sudden death. Antipsychotics are usually only used in cases where there are severe symptoms of challenging and disruptive behaviour that is judged to place you and/or others at risk of harm. They are only used if there is a full discussion between yourself and/or your carer and your care team about the benefits and risks of treatment. Antipsychotics will be prescribed at the lowest dose  possible, and for as short a time as possible. Your health will also need to be carefully monitored  if you are taking antipsychotics. Side effects of antipsychotics can include: drowsiness, shaking, trembling, muscle twitches, spasms, weight gain, blurred vision, constipation, lack of sex drive, and a dry mouth. Preventing Dementia Preventing vascular dementia While it is not possible to prevent all cases of dementia, there are some measures that  can help  prevent vascular dementia, as well as cardiovascular diseases, such as strokes and heart attacks.  As experts in treating dementia often say, What is good for your heart is also good for your head. The best ways to prevent vascular dementia are: Eat a healthy diet. Maintain a healthy weight. Get sufficient and regular exercise.   Drink alcohol in moderation. Dont smoke. Diet To help prevent dementia, a low-fat and  high-fibre diet is recommended. This includes plenty of fresh fruit and vegetables (five portions a day) and wholegrains. Limit the amount of salt that you eat to no more than  six grams  a day. Too much salt will increase your blood pressure, which puts you at risk of vascular dementia. One teaspoonful of salt is about six grams. Avoid eating foods that are high in saturated fat because this will increase your cholesterol level, which also puts you at risk of vascular dementia. Foods high in saturated fat include: meat pies, sausages and fatty cuts of meat, butter, ghee (clarified butter, often used in Indian cooking), lard, cream, hard cheese, cakes and biscuits, and foods that contain coconut or palm oil. Eating some foods that are high in unsaturated fat can decrease your cholesterol level. Foods high in unsaturated fat include: oily fish, avocados, nuts and seeds, and sunflower, rapeseed and olive oils. Weight Being overweight can increase your blood pressure, which increases the risk of vascular dementia. This  risk is higher if you are obese. The most scientific way to measure your weight is to calculate your Body Mass Index (BMI). This is your weight in kilograms divided by your height in metres, squared. In the UK, people with a BMI of between 25 and 30 are overweight, and those with an index above 30 are  obese. People with a BMI of 40 or more are morbidly obese. The best way of tackling obesity is to reduce the amount of calories that you eat, and ensure that you take regular and sufficient exercise. Your GP  can  give you further information and advice about how you can do this. http://www.nhs.uk/Tools/PublishingImages/bmi_tease.gif Exercise Regular exercise will make your heart and blood circulatory system more efficient. It will also  lower your cholesterol level and  keep your blood pressure at a healthy level, all of which will lower your risk of developing vascular dementia. For most people, 30 minutes of vigorous exercise a day, at least five times a week, is recommended. The exercise should be strenuous enough to  make your heart beat faster, and you should feel slightly out of breath afterwards. Examples of vigorous exercise include going for a brisk walk or walking up a hill. Alcohol Drinking excessive amounts of alcohol will cause a rise in your blood pressure, and raise the cholesterol level in your blood. Sticking to the recommended limits for alcohol consumption is the best way to ensure that you reduce the risk of high blood pressure, cardiovascular disease and vascular dementia. The recommended daily levels of alcohol consumption are  three to four  units of alcohol for men, and  two to three  units for women. A unit of alcohol is equal to about half a pint of normal strength lager, a small glass of wine or a pub measure (25ml) of spirits. http://www.nhs.uk/Tools/PublishingImages/do_you_drink_tease.gif Smoking Smoking can cause your arteries to narrow, which can lead to a rise in your blood pressure. It is also a major risk factor for developing cardiovascular diseases, cancer and vascular dementia. The NHS Smoking Helpline offers advice and encouragement to help  you stop smoking. You can call on 0800 022 4332 or visit the NHS Go Smokefree website (see Useful links). Your GP or pharmacist will also be able to give you help and advice about giving up smoking. Preventing other types of dementia There is some evidence that rates of dementia are lower in people who remain as mentally and physically active as possible throughout their lives, and have a wide range of different activities and hobbies. Some activities that may reduce the risk of developing dementia include: reading, writing for pleasure, learning foreign languages, playing musical instruments, taking part in adult education courses, playing tennis, playing golf, swimming, group sports, such as bowling, and walking. There is no evidence that playing brain training computer games reduces the risk of dementia. Dementia (souce,Bupa) reventing vascular dementia While it is not possible to prevent all cases of dementia, there are some measures that  can help  prevent vascular dementia, as well as cardiovascular diseases, such as strokes and heart attacks.  As experts in treating dementia often say, What is good for your heart is also good for your head. The best ways to prevent vascular dementia are: Eat a healthy diet. Maintain a healthy weight. Get sufficient and regular exercise.   Drink alcohol in moderation. Dont smoke. Diet To help prevent dementia, a low-fat and  high-fibre diet is recommended. This includes plenty of fresh fruit and vegetables (five portions a day) and wholegrains. Limit the amount of salt that you eat to no more than  six grams  a day. Too much salt will increase your blood pressure, which puts you at risk of vascular dementia. One teaspoonful of salt is about six grams. Avoid eating foods that are high in saturated fat because this will increase your cholesterol level, which also puts you at risk of vascular dementia. Foods high in saturated fat include: meat pies, sausages and fatty cuts of meat, butter, ghee (clarified butter, often used in Indian cooking), lard, cream, hard cheese, cakes and biscuits, and foods that contain coconut or palm oil. Eating some foods that are high in unsaturated fat can decrease your cholesterol level. Foods high in unsaturated fat include: oily fish, avocados, nuts and seeds, and sunflower, rapeseed and olive oils. Weight Being overweight can increase your blood pressure, which increases the risk of vascular dementia. This  risk is higher if you are obese. The most scientific way to measure your weight is to calculate your Body Mass Index (BMI). This is your weight in kilograms divided by your height in metres, squared. In the UK, people with a BMI of between 25 and 30 are overweight, and those with an index above 30 are  obese. People with a BMI of 40 or more are morbidly obese. The best way of tackling obesity is to reduce the amount of calories that you eat, and ensure that you take regular and sufficient exercise. Your GP  can  give you further information and advice about how you can do this. http://www.nhs.uk/Tools/PublishingImages/bmi_tease.gif Exercise Regular exercise will make your heart and blood circulatory system more efficient. It will also  lower your cholesterol level and  keep your blood pressure at a healthy level, all of which will lower your risk of developing vascular dementia. For most people, 30 minutes of vigorous exercise a day, at least five times a week, is recommended. The exercise should be strenuous enough to  make your heart beat faster, and you should feel slightly out of breath afterwards. Examples of vigorous exercise include going for a brisk walk or walking up a hill. Alcohol Drinking excessive amounts of alcohol will cause a rise in your blood pressure, and raise the cholesterol level in your blood. Sticking to the recommended limits for alcohol consumption is the best way to ensure that you reduce the risk of high blood pressure, cardiovascular disease and vascular dementia. The recommended daily levels of alcohol consumption are  three to four  units of alcohol for men, and  two to three  units for women. A unit of alcohol is equal to about half a pint of normal strength lager, a small glass of wine or a pub measure (25ml) of spirits. http://www.nhs.uk/Tools/PublishingImages/do_you_drink_tease.gif

Free trade

Free trade is the path to prosperity for countries, benefiting consumers, producers and governs. It enhances competition and eliminates inefficient firms by requiring better productivity, which enables products to reach consumers at a lower price and variety, and create new Jobs, thereby increasing economic development (Brenan 2007, Para. 4; World Bank 2010, Para. 1). Although free trade has the potential to stimulate a country development and economy growth which benefit all consumers, ICC nations have garnered the majority of the benefits.For instance, Western countries have not permitted the wealth flow keeping their barriers, while developing countries have been persuaded to remove their ones (Stilling cited in Buchanan 2002). Additionally, Food and Agricultural Organization (cited in Mousse and Imitate 2005, Para. 4) states that the low average tariff for agricultural products, which is the income for 2,5 million people in the developing nations (Para. ), has contributed to the decline the economy of these nations.Free trade policy enables the flow of goods and services between countries. Developed and developing nations should be benefited by free trade such as importing and exporting products to others freely without the payment of taxes or quotas. In addition, free trade incentives a nation's development, and also economics rising (World Bank 2010). Free trade could be favorable for everyone whether, like in theory, it happened in practice.According to Still (cited In Buchanan 2002) richer nations are disproportionably benefited more than poorer countries. For example, he states that Western countries have convinced poor countries to cancel their barriers, while they have not done the same. Moreover, Scott (2003, Para. 1) argues that free trade has helped to Increase Inequality In U. S. Even though free trade should create economically equality between richer and poor nations, It does not happen truly.

Investment and Selling Price Essay

Turnhilm, Inc. is considering adding a small electric mower to its product line. Management believes that in order to be competitive, the mower cannot be priced above $139. The company requires a minimum return of 25% on its investments. Launching the new product would require an investment of $8,000,000. Sales are expected to be 40,000 units of the mower per year. Required: Compute the target cost of a mower. 57. The management of Hettler Corporation would like to set the selling price on a new product using the absorption costing approach to cost-plus pricing. The company’s accounting department has supplied the following estimates for the new product: Management plans to produce and sell 4,000 units of the new product annually. The new product would require an investment of $643,000 and has a required return on investment of 20%. Required: a. Determine the unit product cost for the new product. b. Determine the markup percentage on absorption cost for the new product. c. Determine the target selling price for the new product using the absorption costing approach. 58. Bourret Corporation is introducing a new product whose direct materials cost is $42 per unit, direct labor cost is $16 per unit, variable manufacturing overhead is $9 per unit, and variable selling and administrative expense is $3 per unit. The annual fixed manufacturing overhead associated with the product is $84,000 and its annual fixed selling and administrative expense is $16,000. Management plans to produce and sell 4,000 units of the new product annually. The new product would require an investment of $1,022,400 and has a required return on investment of 10%. Management would like to set the selling price on a new product using the absorption costing approach to cost-plus pricing. Required: a. Determine the unit product cost for the new product. b. Determine the markup percentage on absorption cost for the new product. c. Determine the target selling price for the new product using the absorption costing approach.

The 5 Ws (and an H) of Journalism

The  questions  a journalist answers in the lead of a conventional newspaper article are  who, what, when, where, why and how. Also known as  Five Ws and an H  and reporters questions. The 5Ws H formula has been attributed to English rhetorician Thomas Wilson (1524-1581), who introduced the method in his discussion of the seven circumstances of medieval rhetoric: Who, what, and where, by what helpe, and by whose,Why, how and when, doe many things disclose. (The Arte of Rhetorique, 1560) Examples and Observations It is not often one finds a walk-in refrigerator in a private home. When it happens, even the most hard-boiled of home reporters may be so flummoxed that she reverts to the journalism basics: Who? What? When? Where? Why? In this case, the who is simple enough--Neal I. Rosenthal, founder of the wine importing business that bears his name; the where is his newly renovated house in Dutchess County, about two and a half hours north of New York City.But why a fridge you can walk into?Another moment of excesses, Mr. Rosenthal says of the refrigerator, which cost $23,000. He has, after all, just completed the last step in a $3 million-plus renovation.(Joyce Wadler, In Dutchess County, a Wine Merchant’s Renovated Home. The New York Times, June 19, 2008)News stories are about providing information, and there is nothing more frustrating for the reader that finishing a story with unanswered questions still hanging. Journalism students are taught about the five Ws: who, what, when, where and why. They are a useful tool to check you have covered all the bases, though not all will always apply.(Peter Cole, News Writing. The Guardian, Sep. 25, 2008) Journalists questions Who? What? Where? When? Why? How? or the questions that are referred to as the five Ws and one H, have been the mainstay of newsrooms across the country. Likewise, these questions have not lost their value in classroom instruction, regardless of the content area. Having your students answer these questions focuses their attention on the specifics of a given topic.(Vicki Urquhart and Monette McIver, Teaching Writing in the Content Areas. ASCD, 2005) S-V-O Sentences and the 5Ws and an H Subject-verb-object is the preferred sentence organization pattern in journalistic writing. Its easy to read and understand. . . S-V-O sentences pack in enough of the who, what, where, when, why and how for readers to have an overview of the story in one sentence. . .These 5 Ws and an H leads from wire services tell the whole story: AUSTIN—Texas ( where) Destinee Hooker, the two-time defending NCAA high jump champion ( who), will skip track ( what) this season ( when) to train with the U.S. womens national volleyball team ( why) before the Olympics.SALT LAKE CITY—Tag Elliott ( who) of Thatcher, Utah, was in critical condition one day after surgery ( what) to repair extensive facial injuries sustained in a collision with a bull ( why).Elliott, 19, was riding a 1,500 pound bull named Werewolf on Tuesday ( when) in the Days of 47 Rodeo ( where) when their heads smacked together ( how). S-V-O is the preferred sentence order in broadcast as well, because it creates easy-to-say units of thought that listeners can understand and absorb while the sportscaster is speaking. Online readers read in chunks: a blurb, a lead, a paragraph. They, too, are looking for easy-to-read, easy-to-understand information, and thats what S-V-O sentences deliver.(Kathryn T. Stofer, James R. Schaffer, and Brian A. Rosenthal, Sports Journalism: An Introduction to Reporting and Writing. Rowman Littlefield, 2010)

Top Tips of Essay Topics for Fall of the House of Usher

Top Tips of Essay Topics for Fall of the House of Usher Details of Essay Topics for Fall of the House of Usher He just didn't understand when to stop. Nevertheless, you should have seen me. There are merely a few folks. All this and more will have to continue being unsaid for the time being. The main reason why Roderick prematurely buried his sister isn't as simple to explain. The other few plays take place in many locations throughout the mausoleum and cemetery. Feelings that are due to the manner that Poe writes. A love story, which is wholly absent from Poe's unique tale, is a significant component in the movie. Whereas in the House of Usher there are just a few of these events which take place. The house seems to be solid enough but its exterior is wholly covered in fungus. It's this malady that produces his flawed art which then echoes the story of the home of Usher itself. In The Fall of the home of Usher Poe shows tone and mood in a few ways too. Most people have gotten annoyed with Usher, feeling he is too paranoid. I've included an overview of The Fall of the home of Usher'' just in the event you need reminding. His hearing is now heightened. Finding the Best Essay Topics for Fall of the House of Usher In both these situations, character are in a position to attain a sort of life after death questioning the finality of death. The narrator may be a consequence of a childhood trauma, leading to usher having multiple personality disorder. I am interested in being the one battling. As the parents, hence the children. How to Get Started with Essay Topics for Fall of the House of Usher? In its most fundamental meaning, setting in fiction denotes the time and put where the action of a novel or short story occurs. Because of this, the reader will locate it near impossible to place the story down which is unquestionably a credit to Poe's talent and fashion of writing. The way Edgar Allan Poe employs the emotions of the n arrator to improve the descriptions of the home in particular really enables the reader to paint an image of the setting in their mind. The onset of this tale definitely set the stage for an extremely dark and gloomy location. All these texts predate Poe and therefore couldn't demonstrate any contamination of influence from his usage of the genre. Moreover, a number of the other data around word usage is helpful in seeing a difference between both corpora. This isn't an instance of the work generated by our Essay Writing Service. I believe the script presented a great deal more challenges. A Startling Fact about Essay Topics for Fall of the House of Usher Uncovered I've also realised that I have to write another book. Rather than completing all her research and then attempting to compose the whole book at the same time, she researches sections of the story and then writes that portion of the book. One click immediate price quote The mind is a complex thing. The story happens in an unnamed nation, although references to peasants, feudalism and a centuries-old house imply that it isn't set in the United States of america. Vital Pieces of Essay Topics for Fall of the House of Usher There's, naturall y, a limit on the range of pages even our finest writers can produce with a pressing deadline, but usually, we figure out how to satisfy all the clients seeking urgent assistance. To be able to utilize Voyant to carry out a genre analysis, I analyzed the control corpus to be able to receive a general idea about what the prominent texts look like stylistically. After discovering our website, you will no longer will need to bother friends and family with these kinds of requests. Somewhere his path is going to be crossed. As you become older your probability of needing long-term care providers increase. Despite the fact that you pay for homework, we provide those options at no cost. While my findings within this analysis are interesting, there are a few facts that complicate them. She knows, too like every parent. The New Fuss About Essay Topics for Fall of the House of Usher 1994 The greatest historical fiction intends to recreate the feel of both the time and set where the action occurs. The family opt to keep the talisman from the soldier and put it at the mantle. This brief story indicates that if you do well you become rewarded but when you could be bad everything and everyone becomes affected by your actions and can lead to somebody else to fall. Then explain why and how every one of these characters could be regarded as a foil, and (most importantly) discuss the method by which the foil character serves to illuminate certain qualities of a different character. Our capacity to create sense of earth depends on narrative. It's a timeless Gothic story that's extremely intriguing and intriguing all the way through. At the start of the story there's a really negative feeling being attached to the visual appeal of the home. The way it's described and the way it's so mysterious. What Needs to be Done About Essay Topics for Fall of the House of Usher The second is as soon as the narrator notices a fissure running down the center of the house itself. This concept is reinforced when the 2 siblings die together as, when they do, both halves of the home crumble and therefore the reflection disappears as well. He doesn't leave his home and he's got no friends. It turned out to be a little yam bush supporting the backyard wall of his family house.

Orphan Drug Report - 627 Words

Orphan Drug Report An orphan drug is a drug designed to treat a rare disease or condition. For a drug to qualify for orphan status both the drug and disease or condition must meet certain criteria specified in the Orphan Drug Act (ODA). This designation would qualify the sponsor of the drug for developmental incentives which includes waiving of regulator fees, faster or simpler clinical trial and approval process, tax credit or grants to offset research and development, and a period of marketing exclusivity which means no competition for many years. it does not mean that the FDA is less strict when it comes to safety and effectiveness. All of this is specified within the FDA’s implementing regulations at 21 CFR Part 316. It’s†¦show more content†¦There are a great many side effects the most common include fear, increased cough, lack or loss of strength, night sweats and throat irritations The primary means of dosage is through intravenous injection and the strength de pends on the condition it is being used for. These conditions include non-Hodgkins Lymphoma, Rheumatoid Arthritis, Chronic Lymphocytic Leukemia, Wegeners Granulomatosus, Microscopic, Polyangiitis. The life threatening side effects of using Rituxan include abnormal heart rhythm and liver damage. Another example is Gleevec from Novartis Oncology this drug went on to have non-orphan indications; it had sales of $2.4 billion in 2010. The brand name of the drug is Gleevec and the generic name is Imatinib. This drug interferes with the growth of some cancer cells. Gleevec is used to treat certain types of leukemia (blood cancer), bone marrow disorders, and skin cancer, or certain tumors of the stomach and digestive system. The most common side effects include Acid or sour stomach, belching, difficulty having a bowel movement (stool), difficulty with moving, discouragement,excess air or gas in the stomach or intestines, fear or nervousness, feeling sad or empty, feeling unusually cold, full or bloated feeling, increased bowel movements, irritability, lack or loss of strength, loose stools, loss of interest or pleasure, muscle stiffness, night sweats, passing gas,Show MoreRelatedWhy Usa Based Abc Company864 Words   |  4 Pagesgathered in one region to be used for the evi dence of product registrations in another region following the effect of ethnic factors (FDA, 1998).The regulatory attentions for planning a multinational pivotal phase III clinical trial for drug used for rare disease (Orphan drug by the FDA) which is touching less than 200,000 US population comprise the subjects enrolled in the clinical trials, clinical trial investigators, regulatory agencies, institutional review boards (IRB), and ethics committees, recommendingRead MoreThe Issue Of Orphan Drugs1352 Words   |  6 PagesOrphan drugs are drugs that treat rare diseases that are life-threatening, seriously debilitating, or cause serious and chronic conditions that affects only a relatively small number of patients. 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In particular, the disruption of drug supply will be discussed, with a specific focus on drug supply within the province of Ontario. A discussion will ensue surrounding drug pricing and policy, and the ways in which these frameworks can ultimately serve to affect the efficacy of medical treatment and the safety of patients. In addition, the paper will focus on the accountability of multipleRead MoreFederal Drug Policy, And Its Correlation With The Shortage Of Drugs1758 Words   |  8 PagesIn this essay, federal drug policy, and its correlat ion with the shortage of drugs in Canada, will be considered. In particular, the disruption of drug supply will be considered, with a specific focus on drug supply within the province of Ontario. A discussion will ensue surrounding drug pricing and policy, and the ways in which these frameworks can ultimately serve to affect the efficacy of medical treatment and the safety of patients. Finally, the paper will focus on the accountability of multipleRead MoreSirtris Pharmaceuticals: Living Healthier, Longer9149 Words   |  37 PagesTime: Unlocking the Secrets of Longevity Genes† (Scientific American), â€Å"Drink wine and live longer: The exclusive story of the biotech startup searching for anti-aging miracle drugs† (Fortune) and â€Å"Youthful Pursuit: Researchers seek key to Antiaging in Calorie Cutback† (Wall Street Journal) – Sirtris was hoping to develop drugs that could treat diseases of aging, and in so doing had the potential to extend the lifespan of human beings.1 The Sirtris team had, in fact, established a link between resveratrolRead MorePharmacology: Food and Drug Administration and Prescription Drug837 Words   |  4 PagesPHARMACOLOGY AND DRUG ADMINISTRATION MED 1150 CHAPTER 1- Questions: 1, 2,3,4,7,10,11,13,14,15,16,18 CHAPTER REVIEW PAGE 18-20 QUIZ YOUR SELF 1. Describe the linguistic origin/etiology of the following words * Pharmacology: The study of drugs and the interactions with living tissue. * Origin of Pharmacology: Greek word pharmakon meaning medicine or drug * Drug: Any nonfood chemical substance that affect the mind and body. * Origin of Drug: Dutch word droog meaningRead More†¢ to be witness to the process of dying; †¢ loss of love, affection and material support; †¢ an700 Words   |  3 Pagesfor the sick, impact of family dissolution, stigma, discrimination, grief and frustration seriously affects adolescent orphans.( Mekelle Tigray.S. N,2011) As anxiety is one of the symptoms of mental health problems, it is arguably likely to emerge among orphaned children who have been bereaved following the complicated or violent death of a parent. Depression of adolescent orphans Depression is classified as feeling sad, frustrated and hopeless about life, accompanied by loss of pleasure in most activitiesRead MorePersonal Statement : Academic Argument, Academic Analysis, And Proposal900 Words   |  4 Pagessemester I wrote four essays: Informative Report, Academic Argument, Academic Analysis, and Proposal. With each essay, I displayed my strengths and weaknesses and improved them through teaching, drafting, and revising. This Portfolio Essay will reflect on the growth my writing and I have undergone through this semester, as well as areas I could still use improvement on, by reviewing my own work. The first essay I wrote this semester was the Informative Report, which is also the one I scored lowest

Use Of Wireless Industrial Automation System Scope And Challenges

Question: Discus about the Use Of Wireless Industrial Automation System: Necessity, Scope And Challenges. Answer: Introduction The use of wireless technology in industrial automation system offers several potential advantages from reduction of cost regarding the elimination of wiring to the availability of better plant information. In addition, it enhances productivity as well as better asset management. However, there has been a serious security issue since the implementation of wireless automation system in industries. Thus, it is required to analyze the scopes and challenges involved with the use of wireless industrial automation system. Aims and objectives of the study The research aims to evaluate the scopes and challenges for using wireless automation system. The objectives of the study can be described as followed. To identify the role of wireless automation system in industries To identify the necessity of using wireless automation system To find out the scopes and challenges for using wireless automation system To recommend solutions for overcoming the challenges lied in the use of wireless automation system Research questions What is the role of wireless automation system in industries? What is the necessity of using wireless automation system? What are the scopes and challenges for using wireless automation system? How the challenges lied in the use of wireless automation system can be overcome? Literature review: Overview of wireless automation system In order to comprehend the ways in which wireless technology can help in implementation of industrial automation system, it is required to understand the concept of wireless. Wireless automation system includes a wireless network where an automation system is working with system management software, installation of devices or appliance controllers as well as motion and temperature sensors (Tommila et al. 2001). Wireless can work various levels within an industry by several ways. RFID is one of the simples level through which identification of radio frequency can be useful for asset inspection as well as tracking, safety, location and security. On the other hand, wireless sensor network is one of the possible areas where attention is given at current days for having its multiple benefits like condition monitoring, wireless instruments along with measurements (Eia.gov, 2018).Additionally, wireless LANs covers areas like mobile operator terminals, data logging, IT, security and maintena nce. Moreover, one of the significant advantages of wireless system is enhanced workforce productivity. Issues in industrial automation At present days, industry is facing several issues regarding product quality, safety as well as environmental protection. Fewer margins for profits as well as networked manufacturing focus the requirement for integrating global optimization of production facilities. The role of information technology to achieve the goals becomes critical (Frotzscher et al. 2014). Large as well as complicated production systems cannot be managed effectively and safely without the help of computers in managing information along with process control. End users also expect to get enhanced functionality at a reasonable cost. Wollschlaeger, Sauter and Jasperneite (2017) stated that managing knowledge and real-time information with monitoring condition and maintenance of plant, high availability as well as flexibility of upgrades along with life-cycle support are the instances of key requirements. In this regard, system integrator requires efficient tools for developing applications. The issues like providi ng adequate safety training is required for industrial automation system. Human safety and lives can be affected by industrial automation system. Automated information system has changed life as it creates software development. However, wireless automaton system may include issues like safety and privacy issues. The confidential data of employees can be affected by the system. Components and features of wireless automation system In order to mitigate the issues in industrial automation system and provide potential benefits, wireless automation system plays an important role. In an industry, physical process system includes machines and process equipment (Ojha et al. 2015). It leads to whole-party hierarchy where process systems are in distinctive operational states like maintenance, starting up and operating. There are a set of capabilities combined for performing several stages of the process. Designing control system, control tasks detected in co-operation with the users. Recent applications of wireless automation system are the combinations of control products from multiple vendors. In addition, control devices as well as automation elements need to be able for explanation to the designers, human operators as well as other elements of automation (Petit Shladover, 2015). Moreover, changes in products as well as schedules of production and control systems are coped up with different types of unexpected situations. The exception handing feature helps to cover the issues as fault avoidance in order to identify problems, diagnose and take corrective actions for recovery during system operation as well as continuous enhancement based on the problem report (Eia.gov, 2018). Applications and benefits of using wireless automation system Implementation of wireless automation system includes a number of advantages in industry automation. A multitude of protocols included in wireless automation system has emerged for processing communication. It assists in reducing writing and enhanced diagnostic as well as measurement of data (Eia.gov, 2018).In addition, the possibility of remote diagnostics and improved control at field level is achieved with the help of wireless automation system. The system also supports for distribution. The standards do not consist of the application as well as user layers required for achieving device interoperability (Leito, Colombo Karnouskos, 2016). Hence, multiple working groups can be developed for development of specifications for adoption of Ethernet to industrial automation system. Interface for Distributed Automation is known as an industrial group combining Ethernet as well as Web technologies for development of distributed control architectures (Eia.gov, 2018). On the other hand, the markets of wireless communication have been developing rapidly. It has several advantages compared to conventional wiring. It includes flexibility as well as savings in cabling costs. However, radio communication becomes susceptible to electromagnetic interference and consists of limitations in the capacity of transferring data as well as maximum distances between the devices (Aslam et al. 2015). In industrial automation, radio links are used for selected data transfers required for long time. Text messages are delivered short message service. It is applied to the supplying alarm as well as diagnostic information to maintenance technicians and remote operators (Eia.gov, 2018). In addition, the powerful principles of object-oriented programming provide new scopes for control sector. Object orientation as well as associated design approaches such as UML is not generally utilized in order to design control applications. According to Berg Insight, the installed base of wireless IoT devices in industrial automation has reached to 10.3 million in 2014. The report has predicted that the number of wireless IoT devices in the automation networks will increase at compound annual growth rate of 27.2% in order to reach 43.5 million by 2020 (Ali et al. 2015). The use of wireless automation has a number of benefits like installations savings, obtaining better information, economy of scale, operational savings and making safer operations. Challenges for using wireless automation system Although wireless automation system has potential advantages in industries, it has a number of issues and challenges. Any existing radio systems can that satisfy each requirement simultaneously. For WISA sensors communication module, handling of typical air interface is 5 ms whether it needs to be transmitted several times. On the other hand, WirelessHART the latency time in typical installations is theoretically (Whiffen et al. 2016). In addition, the reliability of wireless communication has been proven in a variety of use cases. It has ranges from monitoring to safety critical applications. However, the major obstacle for taking a rapid action of wireless technologies and lack of established industrial standards are seen. In addition, wireless technologies for telecommunication like GSM, GPRS, HSDPA and CDMA have revolutionary impact on personal communication. Wi-Fi based on IEEE 802.11 standard has given pervasive internet access infrastructure at industries. For automation in factories, wireless system has enabled e-manufacturing process. It provides operation efficiency at the organization level (Ratasuk et al. 2015). The radio-frequency identification technology can serve electronic labels for tracking assets and identification of object in the organization. There is lack of support in sensing, processing information as well as actuation by transponders. In addition, there are privacy and security issues lied with the use of wireless automaton system. Research methodology Selection of methodological tools is helpful to conduct the research in proper way. Hence, it is necessary to select appropriate and suitable research philosophy, research approach and design for obtaining appropriate outcome. In addition, process of collecting data and data analysis method helpful to fulfill aims and objectives of the research. Research philosophy Selection of appropriate research philosophy assists in determining the proper way of obtaining details of the research. It also helps in making description of assumption process that is undertaken by researcher while conduction of the research (Lewis, 2015). There are three types of research philosophy taken for research such as interpretivism, realism and positivism (Eia.gov, 2018).In the research, positivism philosophy will be selected. The philosophy will be chosen, as it will be helpful to analyze hidden facts as well as information associated with wireless automation system. On the other hand, interpretivism or realism philosophy will be discarded in the research as the nature of the study will be time-limited. Research approach The research approach is helpful to reveal the format of research. Inductive approach and deductive approach are the two types of research topics such as deductive approach and inductive approach (Vaioleti, 2016). In the context, deductive approach will be used. Selection of the research approach will be justified as it will be helpful to analyze the scopes and challenges involved in using wireless automation system by analyzing several theoretical knowledge. Research design Research design is helpful in describing the framework of research topic. It is also helpful in selecting collection as well as analysis pattern (Vaioleti, 2016). A specific type of approach is usually applied in a research that helps in better explanation of research design. Exploratory, explanatory and descriptive research designs are three types of research design. Descriptive research design will be applied in research, as it will be helpful to provide definition of detailed procedure engaged in the application of wireless industrial automation system. Data collection and analysis method Primary data collection and secondary data collection are two types of data collection method used in a research. Primary data are collected from survey and interviews, whereas secondary data are collected from various relevant secondary sources. In the research, primary data will be collected from online survey. Quantitative analysis method will be followed for analyzing data from survey. Quantitative data applies statistical data, which are useful in order to record data of large sample sizes. Secondary data will be gathered from books, journals and articles that will be analyzed in literature review chapter of the study. Sample and sampling Population is considered as the number of people directly or indirectly involved by the content of the research procedure. In the research, 75 staffs from different organizations where wireless automation system is implemented will be selected for research. Simple random probability sampling method will be used for selecting sample or population of the research. References Ali, S., Qaisar, S. B., Saeed, H., Khan, M. F., Naeem, M., Anpalagan, A. (2015). Network challenges for cyber physical systems with tiny wireless devices: A case study on reliable pipeline condition monitoring.Sensors,15(4), 7172-7205. (https://www.mdpi.com/1424-8220/15/4/7172htm) Aslam, W., Soban, M., Akhtar, F., Zaffar, N. A. (2015). Smart meters for industrial energy conservation and efficiency optimization in Pakistan: Scope, technology and applications.Renewable and Sustainable Energy Reviews,44, 933-943. (https://www.sciencedirect.com/science/article/pii/S1364032115000143) Eia.gov.(2018).Retrieved 16 March 2018, from https://www.eia.gov/totalenergy/data/monthly/pdf/sec7_5.pdf Eia.gov.(2018).Retrieved 21 March 2018, from https://www.eia.gov/totalenergy/data/monthly/pdf/sec2_3.pdf Frotzscher, A., Wetzker, U., Bauer, M., Rentschler, M., Beyer, M., Elspass, S., Klessig, H. (2014, June). Requirements and current solutions of wireless communication in industrial automation. InCommunications workshops (ICC), 2014 IEEE international conference on(pp. 67-72). IEEE. 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(https://ieeexplore.ieee.org/abstract/document/6899663/) Ratasuk, R., Prasad, A., Li, Z., Ghosh, A., Uusitalo, M. A. (2015, February). Recent advancements in M2M communications in 4G networks and evolution towards 5G. InIntelligence in Next Generation Networks (ICIN), 2015 18th International Conference on(pp. 52-57). IEEE. (https://ieeexplore.ieee.org/abstract/document/7073806/) Tommila, T., Vent, O. and Koskinen, K., 2001. Next generation industrial automationneeds and opportunities.Automation Technology Review,2001, pp.34-41.(https://www.researchgate.net/profile/Olli_Ventae/publication/265633244_Next_Generation_Industrial_Automation_-Needs_and_Opportunities/links/54b5410d0cf28ebe92e4e023.pdf) Vaioleti, T. M. (2016). Talanoa research methodology: A developing position on Pacific research.Waikato Journal of Education,12(1). (https://www.wje.org.nz/index.php/WJE/article/view/296) Whiffen, T. R., Naylor, S., Hill, J., Smith, L., Callan, P. A., Gillott, M., ... Riffat, S. B. (2016). A concept review of power line communication in building energy management systems for the small to medium sized non-domestic built environment.Renewable and Sustainable Energy Reviews,64, 618-633. (https://www.sciencedirect.com/science/article/pii/S136403211630301X) Wollschlaeger, M., Sauter, T., Jasperneite, J. (2017). The future of industrial communication: Automation networks in the era of the internet of things and industry 4.0.IEEE Industrial Electronics Magazine,11(1), 17-27. (https://ieeexplore.ieee.org/abstract/document/7883994/)